The Department of pathology was one of the foundation Departments in the faculty of medicine when it was established in 1967. It had four composite clinical departments. The Department of chemical pathology was the pivotal department that coordinated chemical pathology and Hematology under the headship of the sagacious and candid late Dr I. O. K. Udeozo. After the Nigerian civil war, the teaching of medical Biochemistry was largely the responsibility of this department. Prof. K. C. Elliot from Canada contributed immensely to the teaching of Medical Biochemistry and also donated books.

Research is going on in the department in the following areas: Antioxidant Vitamin C
Oxidation in nephritic syndrome
Metabolic disorders
Micronutrients and disease
Lipids and cardiovascular disease
Cations in cardiovascular disease
Immunochemistry-Reproductive Endocrinology-auto antibodies to sperm.